Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Relationship between the duodenal motor activity and the pancreatic exocrine function in chronic liver diseases
Yuzi MIZUKAMI
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1988 Volume 85 Issue 2 Pages 227-235

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Abstract

In order to elucidate the relationship between the duodenal motor activity and the pancreatic exocrine function in chronic liver diseases, the intra-luminal pressure of the duodenum, the flow of pancreaticobiliary juice and plasma motilin levels were measured simultaneously during the pancreozymin-secretin test in 29 patients with chronic liver diseases and 8 patients without liver disease who served as a control. In patients with liver cirrhosis, gastroscopy was performed and the presence of gastric mucosal lesions were studied.
The incidence of phase III activity induced by seretin was lower in the patients with chronic liver diseases than in the control group. Pancreatic exocrine volume was increased in the patients with chronic hepatitis and compensated liver cirrhosis, but decreased in the patients with decompensated liver cirrhosis. The incidence of gastric mucosal lesions was higher in cases with the abscence of secretin induced phase III activity than in cases with the presence of it. Regarding motilin, the changes of the plasma motilin levels were dependent on the phase III activity induced by secretin, therefore motilin was not considered to be the initiator of phase III activity.
In conclusion, an imbalance between the duodenal motility and the flow of pancreaticobiliary juice existed in patients with chronic liver diseases, suggesting that it might be one of the etiology of the gastric mucosal lesions in this disorder.

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© The Japanese Society of Gastroenterology
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