Effect of upper abdominal autonomic denervation on glucagon secretion after intraduodenal glucose administration in dogs

Abstract

To evaluate the effects of upper abdominal autonomic denervation on the regulation of glucagon secretion 10 control dogs, 10 vagotomized dogs, 10 upper abdominal autonomic denervation dogs were investigated by intraduodenal glucose administration. In vagotomized group, responses of glucagon were not significantly different from control group. In upper abdominal autonomic denervation group, glucose, insulin, and glucagon levels were significantly higher than those in control group after glucose loading. By gel filtration analysis, the essential cause of high glucagon response after glucose loading was the increase in MW8000-12000 glucagon. These findings suggested that upper abdominal autonomic denervation augmented the responses of glucagon like immunoreactivity after intraduodenal glucose loading.