Plasma amino acid in patients with alcoholic liver diseases

with special refarence to the reduce of tyrosine

Abstract

The altertion of plasma amino acid concentration were studied in 55 cases with alcoholic iver disease and 23 cases with non-alcoholic, HBsAg positive chronic liver disease. The concentration of Tyrosine (Tyr) was significantly decreased and molar ratio (MR) was elevated in alcoholics on admission. The level of Tyr was rapidly increased after abstinence and intake of food. MR was also decreased.
On admission, the ratio of Tyrosine/Phenylalanine (Tyr/Phe ratio) was markedly decreased, and increased after recovery.
It was considered that these phenomenon wer coused by dministration of alcohol and decrease of food intake. It was useful for diagnosis of alcoholic liver diseases that the low level of Tyr. The elevation of MR and the reduce of Tyr/Phe ratio.