Immunohistological study for the ras oncogene products in colorectal cancer

Abstract

By using anti-NKH-ras and K-ras monoclonal antibodies, paraffin-embeded tissue specimens of 70 cases of colorectal cancers were immunohistologically examined. Correlation between incidence of expression of these oncogens and either of postoperative survival rate and stage of colorectal cancer were calculated.
The positive rate of anti-NHK-ras and K-ras staining were correlated with maximum diameters of tumor, staging, degree of Dukes classification and depth of invasion. Positive and negative rates of between NHK-ras and K-ras staining were well coincident. The cumulative postoperative survival rate of negative casesfor anti-K-ras staining showed a significantly higher survival rate than that of the positive cases.