Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
The effects of a truncal vagotomy on the gallstone formation
Ken SAKAI
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JOURNAL FREE ACCESS

1990 Volume 87 Issue 11 Pages 2473-2482

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Abstract

We have conducted an experiment to examine the effects of a truncal vagotomy on the gallstone formation. Chosen for this experiment were ICR male mice that were given an abdominal vagotomy. While the postoperated mice were on a cholesterol-free diet, we found that, due to the vagotomy, the mole fraction of the cholesterol in the mice's gallbladder bile increased, as did the total protein concentration in their bile.
When being fed foods to promoted a gallstone, the postoperated mice clearly demonstrated a higher rate of gallstones formation than without the vagotomy, and while the choresterol concentration in their bile did not show a significant increase, total protein concentraiton did increase significantly. The rate of a biliary infection also increased. Considering the above, we have concluded that a truncal vagotomy is a factor that promotes the gallstone formation.

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© The Japanese Society of Gastroenterology
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