Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Effect of intraduodenal oligopeptide on rat pancreatic exocrine secretion and release of secretin and CCK
Kyoko SHIMIZU
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Keywords: CCK
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1990 Volume 87 Issue 11 Pages 2509-2516

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Abstract

We investigated whether intraduodenal (id) oligopeptide with three or four amino acids residues (pH 7.0) stimulates pancreatic exocrine secretion and release of endogenous plasma secretin and CCK in anesthetized rats. Id administration of oligopeptides in three doses (25, 100, 400mg/hr) at a speed of 4ml/hr resulted in dose-related increases in pancreatic secretion of pancreatic juice volume, bicarbonate, and amylase outputs (r=0.598, 0.673, and 0.426, P<0.05-0.001), and plasma concentrations of secretin and CCK (r=0.743, 0.425, P<0.001 and 0.05). Intravenous administration of CCK-antagonist, CR1505 (5mg/kg•hr) markedly inhibited oligopeptide-stimulated amylase output, but did not affect pancreatic juice volume and bicarbonate output. These results suggest that id oligopeptide increases pancreatic exocrine secretion and releases endogenous secretin and CCK.

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© The Japanese Society of Gastroenterology
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