1990 Volume 87 Issue 11 Pages 2509-2516
We investigated whether intraduodenal (id) oligopeptide with three or four amino acids residues (pH 7.0) stimulates pancreatic exocrine secretion and release of endogenous plasma secretin and CCK in anesthetized rats. Id administration of oligopeptides in three doses (25, 100, 400mg/hr) at a speed of 4ml/hr resulted in dose-related increases in pancreatic secretion of pancreatic juice volume, bicarbonate, and amylase outputs (r=0.598, 0.673, and 0.426, P<0.05-0.001), and plasma concentrations of secretin and CCK (r=0.743, 0.425, P<0.001 and 0.05). Intravenous administration of CCK-antagonist, CR1505 (5mg/kg•hr) markedly inhibited oligopeptide-stimulated amylase output, but did not affect pancreatic juice volume and bicarbonate output. These results suggest that id oligopeptide increases pancreatic exocrine secretion and releases endogenous secretin and CCK.