大腸癌合併潰瘍性大腸炎2例の組織化学的検討 消化器癌に対するモノクローナル抗体による抗原局在およびムチン染色について

奥隅 淳一; 横田 隆; 沢井 清司; 近藤 慎治; 桑田 克也; 田中 真澄; 山根 哲郎; 山口 俊晴; 藤田 佳宏; 高橋 俊雄; 丸山 恭平; 児玉 正

doi:10.11405/nisshoshi1964.87.181

Two cases of ulcerative colitis with colon cancer

Immunoperoxidase staining using monoclonal antibodies agaist gastrointestinal tumor and mucin staining

Junichi OKUZUMI, Takashi YOKOTA, Kiyoshi SAWAI, Sinji KONDOH, Katsuya KUWATA, Masumi TANAKA, Tetsuro YAMANE, Toshiharu YAMAGUCHI, Yoshihiro FUJITA, Toshio TAKAHASHI, Kyohei MARUYAMA, Tadashi KODAMA

Author information

Junichi OKUZUMI
The First Department of Surgery, Kyoto Prefectural University of Medicine
Takashi YOKOTA
The First Department of Surgery, Kyoto Prefectural University of Medicine
Kiyoshi SAWAI
The First Department of Surgery, Kyoto Prefectural University of Medicine
Sinji KONDOH
The First Department of Surgery, Kyoto Prefectural University of Medicine
Katsuya KUWATA
The First Department of Surgery, Kyoto Prefectural University of Medicine
Masumi TANAKA
The First Department of Surgery, Kyoto Prefectural University of Medicine
Tetsuro YAMANE
The First Department of Surgery, Kyoto Prefectural University of Medicine
Toshiharu YAMAGUCHI
The First Department of Surgery, Kyoto Prefectural University of Medicine
Yoshihiro FUJITA
The First Department of Surgery, Kyoto Prefectural University of Medicine
Toshio TAKAHASHI
The First Department of Surgery, Kyoto Prefectural University of Medicine
Kyohei MARUYAMA
The Third Department of Internal Medicine, Kyoto Prefectural University of Medicine
Tadashi KODAMA
The Third Department of Internal Medicine, Kyoto Prefectural University of Medicine

JOURNAL FREE ACCESS

1990 Volume 87 Issue 2 Pages 181-186

DOI https://doi.org/10.11405/nisshoshi1964.87.181

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Abstract

Surgical specimens from 2 patients with chronic ulcerative colitis accompanied with colon cancer were evaluated by immunoperoxidative staining using monoclonal antibodies A₇ (against human colon cancer), S202 (against human gastric cancer), and anti-carcinoembryonic antigen (CEA). The three monoclonal antibodies were reactive with cancerous tissue, anti-CEA antibody and monoclonal antibody S202 reacted with dysplasia tissues, whereas monoclonal antibody A₇ did not.
Using high-iron diamine technique for mucosubstances (sialomucin and sulfomucin), cancer and dysplasia showed no secretory elements. Surrounding mucosa showed both sialomucin and sulfomucin secretion.

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