1990 Volume 87 Issue 2 Pages 206-210
We studied the clinical significance of serum Gc levels in the sera of patients with acute hepatic necrosis. Gc concentration were measured using an EIA in double sandwich technique with purified Gc as standard. Mean levels of serum Gc were 6.0±7.4mg/dl in fluminant hepatitis, 20.8±13.6mg/dl in acute hepatitis and 39.4±13.8mg/dl in nomal subjects respectively. There was slight correlation between Gc and PTT (P<0.05). In the observation of sequential study in patients with fulminant hepatitis, serum Gc levels of live cases elevated but those of dead cases slightly elevated, thereafter decreased.
These results suggested that serum Gc levels was the useful marker as a grade of liver cell demage and a parameter of regeneration in liver cells.