Effects of glucose ingestion on hepatic hemodynamics in patients with liver disease by per-rectal portal scintigraphy using ^99mTcO^-₄ (direct intramural administration of radioistope method)

Abstract

Effects of glucose (225ml, 300kcal) ingestion on hepatic hemodynamics was studied in ten patients with liver cirrhosis and eight patients with non cirrhotic liver disease by per-rectal portal scintigraphy using ^99mTcO^-₄ (direct intramural administration of radioisotope method).
Initial portal blood flow index (IP) and collateral index (CI) were calculated from the time activity curve of heart and liver.
The value of IP was not significantly changed between before and after glucose ingestion in cases with liver cirrhosis (before: 0.0160±0.0016, after: 0.0204±0.0106).
In cases with non cirrhotic liver disease, the value of IP was significantly increased after glucose ingestion (before: 0.0381±0.0145, after: 0.0544±0.0194, p<0.02). These findings suggested increase in portal blood flow via inferior mesenteric vein to the cardiac blood flow.
The value of CI before glucose ingestion was significantly increased in cases with liver cirrhosis (0.751±0.156) compared with that in cases with non cirrhotic liver disease (0.517±0.122), but no significant difference in values after glucose ingestion was found between these two groups.