Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Prognostic significance of echogenic lesion within small hepatocellular carcinoma
Toru KANNOHiroko OKAKoshun KIMAkihiro TAMORIKouji OHTAKEHiroki SAKAGUCHINarito KURIOKATetsuo KUROKIYasuhiro MIZOGUCHIKenzo KOBAYASHI
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1992 Volume 89 Issue 1 Pages 55-60

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Abstract

To evaluate prognostic significance of echogenic lesion within small hepatocellular carcinoma (SHCC, _??_2cm in diameter), clinical and pathological findings of 32 cases with SHCC containing echogenic lesion (echogenic SHCC) were compared with those of 55 cases with non-echogenic SHCC. Compared with the non-echogenic SHCC group, the frequency of clinical stage I was significantly higher, and there were significantly more cases with solitary tumor relative to cases with multiple tumors in the echogenic SHCC group.
Histologically, the incidence of the HCC composed of well-differentiated tumor cells corresponding to Edmondson's grade I was significantly higher in the echogenic SHCC group than in the non-echogenic SHCC group. Although HCCs tended to become progressively less differentiated with increasing tumor sizes in the both groups, the process of cellular change appeared to proceed more slowly in the echogenic SHCC group.
Survival rate after tumor detection was 73% at three years, 56% at five years and 48% at seven years and nine years in the echogenic SHCC group, while it was 46% at three years, 42% at five years and 0% at seven years in the non-echogenic SHCC group. The present results showed that the presence of echogenic lesion within SHCC could be useful prognostic indicator.

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© The Japanese Society of Gastroenterology
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