Nippon Shokakibyo Gakkai Zasshi
Online ISSN : 1349-7693
Print ISSN : 0446-6586
Influence of splenectomy on drug therapy for acute liver failure induced by D-galactosamine and lipopolysaccharide in rats
Kohichi KUDOAkitoshi KAKISAKAShinichi KASAIMichio MITO
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Keywords: OK-432
JOURNALS FREE ACCESS

1995 Volume 92 Issue 7 Pages 1051-1057

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Abstract

We studied protective effects of dibutyryl cyclic AMP (DBcAMP 15mg/kg i.p.) and OK-432 (5 KE/body), and the role of the spleen on D-galactosamine (D-Gal 500mg/kg i.p.) and lipopolysaccharide (endotoxin : Et 0.5mg/kg i.p.) induced acute liver failure.
The survival rates were 10% in the control group (D-Gal + Et), 53% in the group I A (DBcAMP was administered at 1 hour before D-Gal administration), 79% in the group I B (Splenectomy was performed at 24 hours before D-Gal administration on the group I A), 87% in the group II A (OK-432 was administered at 24 hours before D-Gal administration), and 64% in the group II B (Splenectomy was performed at 24 hours before D-Gal administration on the group II A). GOT activities and TNF activities were significantly improved in the treatment groups, and in the group I B and group II A, they were more improved than in the group I A and group II B.
In conclusion, spleen had the positive effect for OK-432 treatment, and also had the negative effect for DBcAMP treatment on acute liver failure induced by D-Gal and Et.

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© The Japanese Society of Gastroenterology
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