Radiation and Drug-Induced Intracranial Neoplasm with Angiographic Demonstration

Abstract

Three cases of secondary intracerebral tumor, fibrosarcoma, glioblastoma multiforme and reticulum cell sarcoma-microglioma are reported. Two of the irradiated cases are thought to be radiation-induced. To our knowledge, glioblastoma multiforme following irradiation is the first case reported. A case of reticulum cell sarcoma-microglioma is thought to be induced by immunosuppressive agents. It is difficult to diagnose induced tumors by angiogram, but the possibility of this diagnosis should be borne in mind when dealing with a patient who has had radiation therapy or immunosuppressive agents. The unusual features of the angiogram, other than recurrence of tumor, suggests this possibility.