Neurologia medico-chirurgica
Online ISSN : 1349-8029
Print ISSN : 0470-8105
Clinical Usefulness of 11C-MET PET and 201Tl SPECT for Differentiation of Recurrent Glioma from Radiation Necrosis
Yukihiko SONODAToshihiro KUMABEToshiei TAKAHASHIReizo SHIRANETakashi YOSHIMOTO
Author information
JOURNALS FREE ACCESS

1998 Volume 38 Issue 6 Pages 342-348

Details
Abstract

The clinical usefulness of L-methyl-11C-methionine positron emission tomography (11C-MET PET) and thallium-201 single photon emission computed tomography (201Tl SPECT) for distinguishing glioma recurrence from radiation-induced changes was evaluated. Ten patients with lesions highly suggestive of recurrent glioma on magnetic resonance imaging underwent 11C-MET PET and 201Tl SPECT studies. Two patients were examined twice, so a total of 12 studies were performed. The clinical diagnoses were five recurrent gliomas and seven radiation necrosis. The five recurrent gliomas appeared as increased uptakes on both 11C-MET PET and 201Tl SPECT scans. Four of the seven radiation necrosis lesions also appeared as increased uptakes on the 201Tl SPECT scans. In contrast, only one radiation necrosis appeared as increased uptake on the 11C-MET PET scans. There was no significant difference in 201Tl SPECT indices between radiation necrosis and tumor recurrence, but the ratio of the differential absorption ratio of tumor tissue to that of the homologous contralateral gray matter in PET of recurrent glioma was significantly higher than that of radiation necrosis. 11C-MET PET is superior to 201Tl SPECT for the differentiation of tumor recurrence from radiation necrosis and delineation of the extent of the tumor.

Information related to the author
© The Japan Neurosurgical Society
Previous article Next article
feedback
Top