Temporal PET and MR imaging findings of the bone-marrow on ¹⁸F-FDG PET/MRI after G-CSF administration

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To our knowledge, this is the first case report showing differences in the temporal PET and MR imaging findings of the bone-marrow on ¹⁸F-FDG PET/MRI after G-CSF administration. PET/MRI performed one day after G-CSF administration showed remarkably increased FDG uptake on PET but normal signal intensities on MRI, in the bone marrow. Conversely, there was no increased FDG uptake but high signal intensities on diffusion-weighted imaging and T2 weighted images, 21 days after G-CSF administration. These findings suggest contiguous changes of glucose metabolism and cellularity of activated red bone marrow due to G-CSF administration.