2022 Volume 13 Issue 2 Pages 471-476
To investigate the role of the nonlinearity of input interactions in the neural network, we examined the influence of acetylcholine as a top-down input on the interaction between bottom-up inputs in dentate granule cells in the hippocampus. The results showed that nonlinearity in the interaction between bottom-up inputs was modulated by the top-down input and was related to inhibitory cells. Our findings suggest that nonlinearity in the interaction of inputs plays a key role in coincidence detection, which is regulated by the top-down input. This indicates a crucial role for nonlinearity in the neurodynamics of the hippocampal local network.