The current status of genome sequencing projects for hexaploid wheat and its relatives is reviewed. Wheat genome sequencing has become more feasible following the introduction of various techniques that reduce the complexity of its genome. Aneuploid stocks, namely ditelosomics, allowed us to sort individual chromosome arms by flow-sorting. Chromosome arm-specific DNA samples were prepared from the sorted chromosome arms for sequencing. The assemblies of the shotgun sequencing of the arm-specific DNA samples were published in 2004, where hypothetical wheat gene sequences can be found. This review is a milestone publication for wheat science that marks the dawn of the post-genomic era. I summarized the available molecular marker techniques for wheat.