2010 Volume 69 Issue 6 Pages 352-356
Human herpes virus 6 is a common cause of exanthema subitum in children. Recently, isolated cases of human herpes virus 6 encephalopathy have been reported. We report a case of a 10-month-old boy with acute infantile encephalopathy predominantly affecting the frontal lobes associated with human herpes virus 6. He exhibited convulsive status epilepticus with hyperpyrexia. High signal intensity was evident in the cortex of both frontal lobes on diffusion-weighted magnetic resonance imaging, and decreased perfusion was noted in both frontal lobes with single-photon emission computed tomography. He subsequently developed regression of verbal and motor function, and atrophic changes were observed in both frontal lobes on T1-weighted magnetic resonance imaging. These characteristic findings may reflect a pathogenic mechanism in acute encephalopathy associated with human herpes virus 6.