Diuresis Peptide

Abstract

Atrial natriuretic peptide (ANP) was isolated and identified by Matsuo and Kangawa in 1984. ANP has a diuretic effect, and vasodilation, reduced preload, afterload, various actions through inhbition of the renin angiotensin system, suppression of myocardial hypertrophy, and inhibition of fibrosis have been observed. During cardiac operations performed in our department, we have achieved satisfactory results in overcoming the disadvantages of cardiopulmonary bypass (CPB) by administering a low dose (0.02-0.05γ) intravenous infusion of ANP at the initiation of CPB.