Abstract
Forty-eight young mature mice of both sexes were injected with 5 or 20 mg of vitamin E (“Juvela” prepared by Eisai Co., Ltd. )from 60 days of age. They were sacrificed at various intervals for periods of 1 to 20 days and their pituitaries were histologically examined.
1) Acidophiles did not differ in occurrence from the normal controls. But in some cases large acidophiles are somewhat more numerously encountered at a late stage and they contained commonly a negative image of Golgis apparatus, perinuclear halo and cytoplasmic basophilic substance.
2) Delta cellsd id not differ in occurrence from the normal. They were commonly well granulated, but in some cases of a late stage, heavily granulated delta cells are somewhat more frequently found than in the normal controls.
3) Beta, theta and chro m ophobe cells did not differ in number and cytological detail from the normal.
4) These data indicate that vitamin E administration does not produce a marked influence on the anterior pituitary histology of young mature mice.
