Abstract
Fifty-nine immature mice of both sexes were injected on alternate days with vitamin E (“Juvela” prepared by Eisai Co. ) from 10 days of age onward. These mice were sacrificed at various stages from 20 to 80 days of age. Pituitaries obtained were histologically examined and results were as follows:
1. Delta and theta cells indicated an ear l i er development in histogenesis than in the normal controls.
2. Beta cells also developed s o mewhat earlier than in the normal controls, though less in degree than in delta and theta cells.
3. Acidophiles and chromophobes did not show a n y marked change.
4. From 60 days of age onward, however, many pituitaries of the experimental animals showed a normal appearance in cytological detail.
I wish to express my gratitude to Prof. Dr. K. Yamada for his helpful suggestions in this work.
