1982 年 58 巻 4-6 号 p. 933-943
Zinc in the hippocampal formation was studied by the sulfide silver method at 5,10,15, and 30 min after administration of 200 mg/kg oxine in rats. Specimens obtained at the same stages were also investigated electron microscopically.
In rats at 5 min after the oxine administration, areas with a normal positive reaction for zinc, h3-h5 the of the hippocampal formation adjacent to the stratum pyramidale of the stratum radiatum and stratum multifome of the dentate gyrus, gave a negative reaction. At 15 min after the administration, a slightly positive reaction was noted, and an intense positve reaction was observed at 30 min after the administration.
Electron microscopy revealed a marked decrease of synaptic vesicles in the mossy fiber endings of the rats at 5 min after the oxine administration. At 15 min after the administration, the synaptic vesicles in the mossy fiber endings were considerably increased. At 30 min after the administration, synaptic vesicles were densely accumulated within the endings as in normal animals.
