1. Four infantile cases of Subacute myelo-optico-neuropathy (SMON) were reported.
Clinical characteristics of these cases are that sensory disturbances are not so severe as seen in adult cases and they tend to recover in relatively short period.
Infantile cases of SMON have been considered to be very rare and only seven cases have been reported so far in Japan, but it is assumed that some cases of SMON are overlooked or misdiagnosed because of the different clinical features from those of adult cases.
2. How much doses of chinoform had been administered to children was investigated in a pediatric clinic of a medical college hospital. Though 244 cases were administered it, SMON did not appear.
The dosage per kilogram was the same with adult cases, but duration of administration was less than 14 days in 94.3% of the cases.
