I型アレルギー反応のIgE抗体産生に及ぼす運動の影響

抄録

The present study was carried out on mice and rats to examine the effects of running and swimming on immune responses, particularly IgE antibody and hemagglutinin (HA) production. In the experiment with running mice, four-week old mice were divided into four groups. The first group of mice started running at the age of four weeks (E4 group), the second group started running at the age of seven weeks (E7 group), the third group started running at the age of 10 weeks (E10 group), and the fourth group was a control that received no treatment. In the experiment protocol, each group was subjected to running exercise until the age of 13 weeks. Each group of mice was forced to run at a speed of 15m/min on a flat floor with no slope for 60min a day. In the E4 group, IgE antibody production was suppressed without affecting HA production. In the E7 and E10 groups, neither IgE antibody production nor HA production was affected. In the experiment with swimming rats, seven-week old rats were divided into two groups: the swim group and the control group. The swim group was forced to swim for five days for three 15-min sessions a day loaded with an iron ring weighing 3% of the body weight. The control received no treatment. In the swim group, IgE antibody production was suppressed without affecting HA production. From these results, it might be concluded that running exercise and swimming exercise from early childhood will provide favorable influences on some asthmatic diseases by suppressing IgE antibody production.