Organ Biology
Online ISSN : 2188-0204
Print ISSN : 1340-5152
ISSN-L : 1340-5152
エピジェネティクスにおけるヒストンアセチル化の新展開新規ヒストン修飾H4K20ac と遺伝子発現、細胞増殖について
貝森 淳哉市丸 直嗣猪阪 善隆楽木 宏実高原 史郎
ジャーナル フリー

2015 年 22 巻 2 号 p. 181-183


Previously unknown histone H4 acetylation at Lysine 20 (H4K20ac) was intensively investigated. By mass spectrometry analysis, the existence of H4K20ac in mammalian cells was proved. The genome wide analysis by ChIP seq with a next generation sequencer revealed that H4K20ac was accumulated on the promoter region of weakly expressing genes, which is almost opposite to the conventional view of histone acetylation modifi cations. The motif search of H4K20ac suggested that well-known transcriptional repressor, NRSF can bind to H4K20ac distributed area. Furtherly, gene ontology identifi ed that H4K20ac was implicated in cell growth. New histone acetylation modifi cation, H4K20ac may open new mechanistic insight for cell growth.

© 2015 日本臓器保存生物医学会
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