正常並びに蛋白欠乏時に於ける前頭洞手術創の治癒機転に関する実験的研究

抄録

This study was undertaken in an attempt to investigate influence of proteindeficient condition on healing of operative wound of the frontal sinus from the histopathological standpoint.
The materials used in the present study were 16 dogs, which were divided into two groups according to the manner of diet. Half of them were fed with standard diet and the other half with protein-deficient diet.
The operation of the frontal sinus to remove the mucous membrane within was performed in each one of these animals and the feeding had been continued in the same way until they were put in decapitation for fixation at a certain time different in each case during the period from 10 days to 6 months after the operation.
From histopathological observations on the specimens obtained from these materials, it was revealed that granulation tissue appeared in the operated area turned to be cicatrized in 6 months in the formerrgroup, however, edema and cell infiltration were still observed to remain at the same stage in the latter.
As to the regeneration of epithelium, the appearance of newly formed epithelium with squamous or cuboid form took place in 30 days, that of columner epithelium in 4 months and that of pseudostratified columner epithelium in 6 months in the former group.
On the contrary, regenerated epithelium with squamous or cuboid form appeared in 6 months in the latter group.
In healing process of bony tissue, there were two types observed during this period, in the former group. That is to say ; the one showed an osseous impaction of the cavity in 3 months and the other exhibited cavity formation with involution of primitive medullary cavity and newly formed trabeculae. On the other hand, primitive medullary cavity and newly formed trabeculae of the bone were still observed at this stage of 6 months in the latter group.
The bony window (aperture) at the tegman was found to be closed in 30 days after the operation in the former group, however, it was kept opened even after 6 months in the latter group.
The mucous membrane remained in the sinus displayed, in both groups, cell infiltration and edema in submucosal tissue and it appeared to impair development of granulation tissue.
Marked lose of weight in the protein-deficient group was observed only in cases subjected to long standing experiment.
From these results, the author gathered that protein-deficient condition was considered as a deterrent factor of healing mechanism of operative wound.