Histopathological changes are investigated in the tongue of the guinea pig after freezing for one and a half minuters at-60°C Atrophy of the muscle fibers and an increase in vascular permeability were found to have occurred immediately after cryosurgery. Approximately 24 hours after freezing, the stratified squamous cell epithelium covering the surface of the tongue had desquamated.
The majority of the muscle fibers had atrophied and both inflammatory and cicatricial reactions were noted in the frozen lesion. Seven days after surgery, the treated lesion was completely replaced by scar tissues and subsequently was covered with newly formed squamous cell epithelium.
