Although the causes of inner ear hearing defect are versatile, disturbances in the microcirculation and metabolism of the hair cells have been considered to be the major factors.
Because of the effective barrier system in the inner ear, which appears primarily due to tight junction of the endoethlial cells, drugs are usually unable to gain access to the inner ear.
Loop diuretics have been known to affect the striae vascularis and open up the inner ear barrier allowing, though trasiently, the circulation of drugs into the inner ear.
The authors report his experience with treatments of sensory hearing loss by Nakai's method. Results were fairly good.