副鼻腔炎に対するリゾチームの影響に関する実験的ならびに臨床的研究
実験的副鼻腔炎に対する効果と臨床例における抗生物質との併用効果を中心に
1986 年 29 巻 Supplement1 号 p. 31-39
詳細
1986 年 29 巻 Supplement1 号 p. 31-39
Efficacy of lysozyme in experimentally induced sinusitis in rabbits was determined in a morphological study. Examination under light and scanning electron microscopes revealed a marked improvement in sinusitis in the group of rabbits treated with lysozyme chloride at a dose of 100mg/kg/day for one week, the rate of improvement being higher in the lysozyme group than in the control.
The effect of combination therapy with lysozyme chloride and an antibiotic (Cefmenoxime) in human chronic sinusitis was also evaluated. The delivery of the antibiotic to the maxillary sinus membrane tended to be facilitated to a greater extent in the combination therapy group than in the group receiving the antibiotic alone, and a tendency was noted that the difference in drug delivery was statistically significant.
