オゾン暴露のマウス肺及び鼻粘膜に及ぼす影響とヒスタミンの関与

抄録

The effect of exposure to ozone (O₃) on histamine release in lung and nose was investigated in BALB/C mice, W/W^v mice and +/+ mice.
BALB/C mice were continuously exposed to 0.8ppm O₃ for 3 hours, 1 day, 3 days or 7 days. W/W^v mice and +/+ mice were continuously exposed to 0.8ppm O₃ for 7 days.
In BALB/C mice, the increase in weight of the lung was observed in 1 day, 3 days and 7 days exposure to ozone, but no significant change was observed in histamine contents of the lung through all exposure periods.
In +/+ mice which has mast cells, the increased weight of lung were observed, though no significant change was observed in W/W^v mice which defects mast cell.
These results suggest that O₃ exposure has the effect on histamine release which causes the increased weights of lung, though there is no decrease of histamine contents.