Abstract
Collagen sponge is made from a mixture of fibrillar and heat-denatured bovine atelocollagen stabilized by dehydrothermal cross linking. It shows a decreased foreign body reaction and has greater stability. I have obtained good results by applying this material in middle ear surgery. I report here my experience of its usefulness as a graft material for dermal, mucosal and connective tissue defects of the external and middle ear.