Abstract
Perfusion of Gentamicin through the perilymphatic space showed specific fluorescence distributed in the cochlea, especially in the outer hair cells, basement membrane and basilar crest. Although no fluorescence was seen in the cochlea treated with high dose of Gentamicin administered intraperitoneally, only type I hair cells in the vestibule were selectively stained with FITC. Futhermore some of the vestibular ganglion cells were also stained. We suppose that the difference of toxic effect between each aminoglycoside antibiotics is due to the selectiveness of receptor of each type of hair cells.
