FurosemideのEP低下作用に対するDextranの効果について
1984 年 15 巻 1 号 p. 296-298
詳細
1984 年 15 巻 1 号 p. 296-298
It became evident in our previous studies that glycerol and isosorbide, both hyperosmotic agents, potentiate the EP-decrease caused by furosemide because of their osmotic opening actions at the blood-cochlea barrier. Dextran which has a high colloidal osmotic pressure is considered to exert an effect on water migration across the blood vessel walls. The present study using dextran failed to reveal any potentiation of EP-decrease caused by furosemide. Thus it could be assumed that dextran does not possess any effect on the permeability of the blood-cochlea barrier as far as furosemide is concerned.
