Ear Research Japan
Online ISSN : 1884-5797
Print ISSN : 0288-9781
ISSN-L : 0288-9781
Pathological change of the round window membrane induced by endtoxin
M. SatohN. SakaiS. FukudaY. InuyamaK. Tanaka
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JOURNAL FREE ACCESS

1990 Volume 21 Issue 1 Pages 53-54

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Abstract

Progressive change of the round window membrane (RWM) after daily injection of endtoxin (Sigma, 10μg/ml, 50μg/ml) in the middle ear cavity were obsered by electron microscopy and the permeability change of the RWM was examined using horse radish peroxidase (HRP) as a tracer. Three days after first injection of endtoxin, mild edema ocurred in the subepithelial space of the RWM, and small number of granulocyte and a few mononuclear cells appeared. After seven days, edematous changae of the RWM was more pronounced than that in the three days group, and further, destruction of the inner layer was found sporadically.

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© Japan Otological Society
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