Ear Research Japan
Online ISSN : 1884-5797
Print ISSN : 0288-9781
ISSN-L : 0288-9781
エンドトキシンによる正円窓膜病変の電顕的観察
佐藤 公輝酒井 昇福田 諭犬山 征夫田中 克彦
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1990 年 21 巻 1 号 p. 53-54

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Progressive change of the round window membrane (RWM) after daily injection of endtoxin (Sigma, 10μg/ml, 50μg/ml) in the middle ear cavity were obsered by electron microscopy and the permeability change of the RWM was examined using horse radish peroxidase (HRP) as a tracer. Three days after first injection of endtoxin, mild edema ocurred in the subepithelial space of the RWM, and small number of granulocyte and a few mononuclear cells appeared. After seven days, edematous changae of the RWM was more pronounced than that in the three days group, and further, destruction of the inner layer was found sporadically.

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