Na+/H+交換輸送体: 生体プロトン環境を制御するイオントランスポータ
2004 年 14 巻 3 号 p. 262-267
詳細
2004 年 14 巻 3 号 p. 262-267
The Na+/H+exchanger (NHE, SLC9) is a membrane transporter that catalyzes the electroneutral counter-transport of Na+for H+.NHE is involved in various physiological and pathological aspects such as maintenance of ionic homeostasis, cell volume regulation, transepithelial transport of electrolytes, cell growth and apoptosis. To date more than 10 different NHE isoforms have been identified and their molecular and cellular biochemistry has been extensively studied. In this report, we will briefly summarize the structurefunction of NHE, particularly focusing on our recent findings.
