内耳障害後の前庭有毛細胞の回復
カルモジュリン染色を有毛細胞の指標とした評価
1997 年 7 巻 5 号 p. 574-578
詳細
1997 年 7 巻 5 号 p. 574-578
The vestibular hair cell recovery after transtympanic administration of gentamicin (GM) in the gerbil was examined by use of immunocytochemical labeling for calmodulin, a hair cell marker. Nine animals were treated with transtympanic injection of GM for 5 days. Three animals were killed at 1 week, 2 weeks, and 4 weeks post-treatment (PT). Another two animals were untreated for a control. Twelve sections in the central region of the utricle of each animal were used for the calmodulin labeling. Hair cells stained with antibodies to calmodulin were 25.6/section at 1 week, 34.6 at 2 weeks, 38.4 at 4 weeks PT in number. The results indicated that hair cells showed recovery in number based on immunocytochemical labeling for calmodulin.
