Results of Recent Research on Endolymphatic Hydrops

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Administration of vanadate or ouabain on the round window did not produce a significant change in the position of Reissner's membrane, but ouabain produced more adverse effects on the cochlear and vestibular sensory cells and limbus spiralis. Pressure application to hydropic animal ears through the external auditory canal elicited nystagmus at lower pressure in comparison to normal ears. Maxzide (potassium sparing diuretic) treatment had no effect on the development of endolymphatic hydrops. Perforation of the tympanic membrane or a tube insertion into the bulla was effective to inhibit growth of hydrops.