2023 年 56 巻 p. 30-35
Glioblastoma (GBM) cells use multiple ways of communication with the tumor microenvironment to tune it for their own benefit. Among these, extracellular vesicles (EV) have emerged as a focus of study in the last few years. Polyphenols and saponins are reported to have many advantages for anti-cancer effects such as high accessibility, low toxicity, and specificity of response, but have limited usage in clinics because of their poor bioavailability and rapid metabolism. Therefore, it would be useful to find a new drug delivery system to improve the bioavailability of natural products in vivo. In this paper, we present on the possibility of using a variety of steroid saponins to treat GBM cells with the purpose of increasing the autophagic potential thereby resulting in an increase of EV production. As an end result, we concluded that the pathway of action differs depending on the concentration. Steroid saponins may have increased EV production by activating autophagy through acid β-glucosidase (GBA) activation.