A06 キチンハイドロゲル担体からのガーリック酸の超音波刺激による放出挙動

抄録

Ultrasound (US) stimulated drug release was examined by using chitin hydrogel matrix loaded with gallic acid (GA), which was used as the drug for wound healing and anticancer agents. The GA-chitin hydrogels were prepared from chitin-dimethylacetamide (DMAc)/lithium chloride (LiCl) solution in the presence of GA by phase inversion method, when the solution was exposed to water vapor for 24 h. The GA release from the GA-chitin hydrogel was researched under different US powers of 0-30 W at 43 kHz. The effect of chitin concentrations (0.1, 0.5 and 1 wt%) on the release behavior was also studied under 43 kHz US exposure at 30 W, respectively. It was noted that the US accelerated release efficiencies for all the samples. Besides, the release efficiency increased as increasing of the US power and the decreasing of chitin concentration in the hydrogel matrix. The release rate of 0.73 μg/mL·min was obtained from the 0.54 mg/cm³ of GA loading hydrogel, which was fabricated from 0.1 wt% chitin mixture solution, when 43 kHz US exposure at 30 W was exposed. This efficiency was 9.1 times higher than the sample without US exposure.