An 80-year-old female experiencing a loss of appetite was referred to our hospital. Drug-induced hypercalcemia was suspected as a possible cause. There was a persistent increase in unexplained inflammatory response and fever, resulting in the initiation of ceftriaxone (CTRX) treatment.
Subsequently, although her symptoms improved, blood tests revealed increased liver and biliary enzyme levels, and abdominal CT tomography revealed gallbladder and common bile duct stones. As the same findings were not observed on abdominal CT at the time of admission, ceftriaxone-related pseudolithiasis was suspected.
Due to the presence of cholangitis, endoscopic retrograde cholangiopancreatography, biliary stone extraction, and drainage were performed. Based on the clinical course, a high possibility of CTRX-associated pseudolithiasis was considered.
