Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology)
Online ISSN : 1880-408X
Print ISSN : 0385-0110
ISSN-L : 0385-0110
Original Work
Relationship between bone-type alkaline phosphatase levels in gingival crevicular fluid and clinical parameters during supportive periodontal therapy
Sunao UeharaHiroshi ItoShuichi HashimotoYukihiro Numabe
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2018 Volume 60 Issue 1 Pages 26-34


Periodontal tissues such as periodontal ligaments are known to have high alkaline phosphatase (ALP) activity, and the genotype of ALP in periodontal ligament is reported to the bone-type. Therefore, if periodontal tissues are damaged by periodontitis, bone-type ALP (BAP) may be released in gingival crevicular fluid (GCF). The aim of this study was to compare the values of BAP in the GCF in patients during supportive periodontal therapy (SPT) with clinical parameters, as a contribution to knowledge regarding early clinical diagnosis of the disease. Thus, we sampled GCF from healthy sites (probing depth (PD) ≤4 mm and bleeding on probing (BOP) (-) ) and diseased sites (PD ≥4 mm and BOP (+) ) from 76 patients receiving SPT. We then measured clinical parameters; plaque index (PI), amount of GCF, gingival index (GI), PD, clinical attachment level (CAL), BOP and alveolar bone resorption. Biochemical parameters included the amount of BAP, aspartate aminotransferase (AST) activity and amount of protein. In addition, we defined a cut-off value for the amount of BAP for analysis.

The results demonstrated that diseased sites were significantly higher for all clinical and biochemical parameters than healthy sites. Furthermore, in an analysis using the cut-off values, those above the cut-off value in healthy sites had significantly higher values of AST activity and amount of protein when compared those with less than the cut-off value. Therefore, the amount of BAP may be related to condition of periodontal health. Based on this study, the amount of BAP in GCF may be indicative of early periodontal tissue damage.

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© 2018 by The Japanese Society of Periodontology
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