1978 年 20 巻 3 号 p. 260-266
In the majority of cases, the oral cavity is usually the principal source of had breath. The volatile sulphur compounds, especially CH3SH, are closely related with odour intensity and produced through the putrefactive action of microorganisms on proteinous substances. It is especially accentuated in tissue degenerative conditions such as periodontitis and acute necrotic ulcerative gingivitis. On the other hand, dilute hydrogen peroxide solution (H2O2) has been used as an antiseptic, wound cleanser and deodorant.
The purpose of this investigation was to study the effectiveness of H2O2 (0.75%) on CH3SH from eriodontal patients. The subjects, aged 20 to 45, were selected from the periodontal patients with bad breath. The sampling method of mouth air and measuring method of CH3SH were previously described by Kaizu.
The results were as follows:
1. The gas chromatographic analysis of mouth air revealed the presence of distinctively separated three sulphur peaks, which were H2S, CH3SH and (CH3)2S and emerged within approximately 10min after injection of mouth air sample. Each subject showed much amount of CH3SH in mouth air, ranging from 3 to 20ng/5ml of mouth air, which was over-threshold levels of CH3SH.
2. The water rinse temporarily caused a pronounced reduction in CH3SH content in all subjects, but in most subjects the effect of water rinse was rapidly dissipated in 30min. After that there was slight increase in CH3SH content.
3. In all subjects, the effect of H2O2 rinse on CH3SH content in mouth air was prolonged over longer duration than was observed following the usage of the water rinse. At 120min after H2O2 rinse, reduction values of 90% were observed. In addition, from the organoleptic stand point of view, bad breath was deppressed at least 120min after H2O2 rinse.
It was therefore concluded that this GC-FPD detection system seemed to be potentially useful in the clinical objective evaluation of mouth air and H2O2 rinse was useful to deppress the bad breath from periodontal patients at least 2 hours.