Abstract
The purpose of this study was to evaluate the periodontal response following implantation of differ-ent types of hydroxyapatite granules (size: 400630μ) in experimental periodontal defects of two mon-keys. 3-wall wide periodontal osseous defects with exposed root surface were prepared for this experi-ment. After surgical debridement of these periodontal defects, 3 types of hydroxyapatite (HA) granules 1) B type porous HA fabricated by H2O2 bubbles method 2) F type porous HA fabricated by polyurethane form method 3) dense HA granules, were implanted res-pectively. Non-implanted, surgically debrided defects served as controls. During the experimental period, plaque control was performed 3 times a week. Then, monkeys were sacrificed at 12 weeks postoperatively.
The results were as follows:
1. Clinically, the healing process was uneventful in four groups. 2. Histologically, new bone formation was found in four groups. In the HA implantation groups, new bone deposited on the surface of HA granules directly without a lining of fibrous connective tissue. In B type porous HA group, HA granules were usually conjugated each other by new bone.
3. The B type HA group showed the greatest amount of connective tissue attachment in four groups and significantly greater than control group.
4. The “defect fill” of three implantation groups (filled with new bone and HA) were significantly greater than the “defect fill” of control group (filled with new bone) and B type porous HA group showed the greatest “defect fill” in four groups.
From these results, it suggest that B type porous HA granules may be more favorable to use in perio-dontal treatment than others two types of HA.
