Abstract
I conducted a fundamental examination to apply an atelocollagen membrane chemically treated with cross-linking, to guided tissue regeneration technique (GTR), as a method of facilitating tissue regeneration after periodontal surgery. Twenty -eight mongrel adult dogs were used . The bony defect of dehiscence type was artificially prepared at the bilateral fourth premolars of the lower jaw on the buccal sides. After root planing, the wound healing was histopathologically examined at 4 and 6 weeks after surgery, in the three groups of the dogs with implantation of atelocollagen membranes cross linked chemically with different degrees (Col.× 0, Col.× 0.5, Col.× 10), and a group w (ithout implantation (Control). As a result, application of the atelocollagen membrane cross linked chemically (Col.× 0.5, Col.× 10) enabled the following: (1) to delay the time of membrane's dissolution in the body without prolongation of local inflammatory responses after membrane implantation, and 2) to suppress the epithelial downgrowth, and to increase the amounts of cementogenesis and osteogenesis, without causing excessive resorption of the roots of teeth. Thus, the GTR method using the atelocollagen membrane cross-linked chemically can be advantageous as a regenerative treatment in periodontal surgery.
