Periodontal Regeneration Using rhBMP-2 in Middle-aged Beagles
2003 Volume 45 Issue 1 Pages 33-42
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2003 Volume 45 Issue 1 Pages 33-42
Periodontal disease is common in middle age. This study investigated periodontal regeneration using rhBMP-2 in middle-aged beagles.
Horizontal periodontal defects at buccal sites were surgically produced, rhBMP-2 combined with polylactate-polyglycolate-copolymer/gelatine sponge complexes (PGS) were then implanted on the planed root surfaces in 6-year-old beagles (MB) and 14-month-old beagles (YB). PGS were implanted in the same manner in 6-year-old beagles (MP) and 14-month-old beagles (YP).
Twelve weeks after implantation, the animals were sacrificed and serial sections were prepared. A histometrical analysis was then performed on periodontal regeneration.
The MB showed a significantly higher rate (42±19%) of newly formed alveolar bone than the MP (14±8%) (p<0.01), while no difference was observed between the MB and the YB (43±22%). The rate of newly formed cementum in the YB (56±21%) was significantly higher than that in the YP (33±12%) (p<0.05), while no difference was observed between the MB (41±13%) and the MP (28±8%).
Our results suggest that middle-aged beagles and young-adult beagles may have an equal potential to augment alveolar bone by the implantation of rhBMP-2/PGS, whereas the potential for cementum augmentation is not as high in middle-aged beagles as it is in young-adult beagles. J Jpn Soc Periodontol, 45: 33-42, 2003.
