2005 Volume 16 Issue 4 Pages 283-289
A 32-year-old expectant woman, who had been diagnosed with congenital antithrombin III (AT III) deficiency (type I) at 21 of age suffering venous thrombosis of the superior sagittal sinus, was admitted to our institute for treatment for deep vein thrombosis on her 8th week gestation. The patient underwent antithrombotic therapy with supplemental human AT III (three times in over the course of a week) and heparin infusion (daily) according to the serum D-D dimer level and AT III activity from the time of admission until 16th week gestation. Anticoagulant therapy with warfarin was initiated succession to daily heparin infusion to improve ADL (activities of daily living). Fetal cardiac sound suddenly stopped and ventricle of the brain expanded on the 24th week gestation. The fetus died as a result of cerebral bleeding. Since the patient had exhibited an allergic reaction to the iodine contrast material, she was immediately examined with pulmonary perfusion scintigraphy and magnetic resonance imaging for detection of any pulmonary embolism after the stillbirth. These examinations found no blood flow in the right upper lung and occlusion of the inferior vena cava.
