Lithographic Techniques for the Fabrication of Oligonucleotide Arrays

Abstract

Miniaturized arrays of immobilized oligonucleotide probes have immense potential as tools for the rapid analysis of DNA sequences. There are a variety of techniques that can be used to fabricate these arrays including robotic spotting, ink-jet printing, and photolithographic patterning. In this report we will provide an overview of microarray technology and describe recent efforts at developing photoresist based techniques for array fabrication.