Proceedings of the Japan Academy, Series B
Online ISSN : 1349-2896
Print ISSN : 0386-2208
Original Articles
Novel plasma biomarker surrogating cerebral amyloid deposition
Naoki KANEKOAkinori NAKAMURAYukihiko WASHIMITakashi KATOTakashi SAKURAIYutaka ARAHATAMasahiko BUNDOAkinori TAKEDAShumpei NIIDAKengo ITOKenji TOBAKoichi TANAKAKatsuhiko YANAGISAWA
Author information
JOURNALS FREE ACCESS FULL-TEXT HTML

Volume 90 (2014) Issue 9 Pages 353-364

Details
Full Text-HTML Download PDF (1447K) Contact us
Abstract

Alzheimer’s disease (AD) is the most common and devastating dementia. Simple and practical biomarkers for AD are urgently required for accurate diagnosis and to facilitate the development of disease-modifying interventions. The subjects for the study were selected on the basis of PiB amyloid imaging by PET. Forty PiB-positive (PiB+) individuals, including cognitively healthy controls (HC), and mild cognitive impairment and AD individuals, and 22 PiB-negative (PiB−) HC participated. Employing our novel highly sensitive immunoprecipitation-mass spectrometry, we measured plasma amyloid β-proteins (Aβs; Aβ1-40 and Aβ1-42) and Aβ-approximate peptides (AβAPs), which were cleaved from amyloid precursor protein (APP). Among the AβAPs, APP669-711 appeared to be a good reference for deciphering pathological change of Aβ1-42. We evaluated the performance of the ratio of APP669-711 to Aβ1-42 (APP669-711/Aβ1-42) as a biomarker. APP669-711/Aβ1-42 significantly increased in the PiB+ groups. The sensitivity and specificity to discriminate PiB+ individuals from PiB− individuals were 0.925 and 0.955, respectively. Our plasma biomarker precisely surrogates cerebral amyloid deposition.

Information related to the author
© 2014 The Japan Academy
Previous article Next article

Altmetrics
Recently visited articles
feedback
Top