Synthesis and Cell Adhesion of Poly(Arg-Gly-Asp-Ser-Pro)

抄録

A sequential polypeptide containing a core peptide of cell-adhesion proteins, poly-(Arg-Gly-Asp-Ser-Pro), was synthesized. The monomeric peptide Arg-Gly-Asp-Ser-Pro had a regular secondary structure, which seemed to be β-turn. On the other hand, the polypeptide did not have a regular structure. The polypeptide inhibited cell adhesion and spreading on fibronectin-coated dish, to nearly the same extent as the monomeric peptide.