Insights into the Golgi apparatus through unicellular algae -Effects of brefeldin A on the Golgi apparatus-

Tetsuko Noguchi

doi:10.5685/plmorphol.13.51

単細胞藻類を用いたゴルジ体系の解析

- Brefeldin Aがゴルジ体系に及ぼす影響-

野口哲子

著者情報

ジャーナルフリー

2001 年 13 巻 1 号 p. 51-60

DOI https://doi.org/10.5685/plmorphol.13.51

詳細

発行日: 2001 年受付日: - J-STAGE公開日: 2010/06/28 受理日: - 早期公開日: - 改訂日: -
訂正情報
訂正日: 2010/06/28 訂正理由: - 訂正箇所: PDFファイル訂正内容: -

訂正日: 2010/06/28 訂正理由: - 訂正箇所: 著者情報訂正内容: 訂正前 : 野口哲子
訂正後 : 野口哲子¹⁾

訂正日: 2010/06/28 訂正理由: - 訂正箇所: キーワード情報訂正内容: Wrong : Key words: Botryococcus, brefeldin A, Golgi apparatus, retrograde transport, Scenedesmus
Right : Botryococcus, brefeldin A, Golgi apparatus, retrograde transport, Scenedesmus

訂正日: 2010/06/28 訂正理由: - 訂正箇所: 引用文献情報訂正内容: Wrong : E
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Cole, N. B., Ellenberg, J., Song, J., DiEuliis, D., Lippincott-Schwartz, J.(1998)Retrograde transport of Golgi-localized proteins to the ER. J. Cell Biol. 140: 1-15.
Driouich, A., Zhang, G. F., Staehelin, L. A.(1993)Effect of Brefeldin A on the structure the Golgi apparatus and on the synthesis and secretion of proteins and polysaccharides in sycamore maple(Acer pseudoplatanus)suspension-cultured cells. Plant Physiol. 101: 1363-1373.
Farquhar, M. G., Hauri, H. P.(1997)Protein sorting and vesicular traffic in the Golgi apparatus. In The Golgi Apparatus. Edited by E. G. Berger, Roth, J. Birkhauser Verlag/Basel Boston, Berlin. pp 63-129.
Fujiwara, T., Oda, K., Yokota, S., Takatsuki, A., Ikehara, Y.(1988)Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum. J. Biol. Chem. 263: 18545-18552.
Jackson, M. R., Nilsson, T., Peterson, P. A.(1993)Retrieval of transmembrane proteins to the endoplasmic reticulum. J. Cell Biol. 121: 317-333.
Kreis, T. E., Goodson, H. V., Perez, F., Ronnholm, R.(1997)Golgi apparatus-cytoskeleton interactions. In The Golgi Apparatus. Edited by E. G. Berger, J. Roth. Birkhauser Verlag/Basel Boston, Berlin, pp 179-193.
Lippincott-Schwartz, J., Yuan, L. C., Bonifacino, J. S., Klausner, R. D.(1989)Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER. Cell 56: 801-813.
Lippincott-Schwartz, Yuan L, Tipper C, Amherdt M, Orci L, Klausner R. D.(1991)Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic. Cell 67: 601-616
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Noguchi, T.(1989)Vacuole development in cells of Micrasterias crux-melitensis treated with cytochalain B. Plant Morphology 1: 15-18.
Noguchi, T., Watanabe, H., Suzuki, R.(1998)Effects of brefeldin A on the Golgi apparatus, the nuclear envelope, and the endoplasmic reticulum in a green alga, Scenedesmus acutus. Protoplasma 201: 202-212.
Noguchi, T., Kakami F(1999)Transformation of trans-Golgi network during the cell cycle in a green alga, Botryococcus Braunii. J Plant Res 112: 175-186.
Noguchi, T., Watanabe, H.(1999)Brefeldin A effects on the trans-Golgi network and Golgi bodies in Botryococcus braunii are not uniform during the cell cycle. Protoplasma 209: 193-206.
Satiat-Jeunemaitre, B. Hawes, C.(1992)Redistribution of a Golgi glycoprotein in plant cells treated with brefeldin A. J. Cell. Sci. 103: 1153-1166.
Satiat-Jeunemaitre, B. Hawes, C.(1993)Insights into the secretory pathway and vesicular transport in plant cells. Biol Cell 79: 7-15
Spang, A., Schekman, R.(1998)Reconstitution of retrograde transport from the Golgi to the ER in vitro. J. Cell Biol. 143: 589-599.
Tanaka, Y., Noguchi T.(2000)Cytoskeleton mediating transport between the ER system and the Golgi apparatus in the green alga Scenedesmus acutus. Eur. J. Cell Biol. 79: 750-758.
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抄録

要旨:ゴルジ体から小胞体系(ER系)への逆行輸送が植物細胞でも存在する証拠を得る目的で、ER系とゴルジ体が近接している藻類細胞二種(単細胞緑藻Scenedesmus acutusとBotryococcus braunii) を用い、brefeldin　A(BFA)がゴルジ体とER系の微細構造に及ぼす影響およびBFA処理によってゴルジ体標識酵素のチアミンピロフォスファターゼがER系に移行するか否かを細胞周期のいろいろな時期について調べた。その結果、BFAによって誘導されるゴルジ体からER系への逆行輸送は哺乳類の細胞だけに特有な現象ではなく、植物細胞にも共通の現象であることが示唆された。この逆行輸送は、二種の藻類ともに、間期の細胞では誘導されたが、分裂期の細胞では誘導されなかった。更に、この逆行輸送にはアクチンフィラメント系が関与し、微小管系が関与している哺乳類の細胞とは異なる機構であることが判った。

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